January 15, 2017
Are you interested in programming and open-source development projects? Want to know what it is like to do some real research? Well, this year the Biocompute Lab has joined the global Google Summer of Code (GSoC) scheme that offers student developers stipends to write code for various open source projects. Our project will focus on improvements to a genetic circuit visualisation tool called DNAplotlib to enable beautiful renderings of complex biological designs and to support the development of the next-generation of visualisation pipeline. Successful students will be mentored by Thomas Gorochowski (University of Bristol, UK) and Bryan Bartley (University of Washington, USA). For more details about the scheme and how to apply check out the National Resource for Network Biology (NRNB) GSoC page: http://www.nrnb.org/gsoc.html, and for specific information about our project check out: DNAplotlib GSoC Project
August 18, 2016
Several members of the lab helped with the conception and development of the Dynamic Cell installation for Einstein's Garden at the Green Man Festival this year. There was music, graphs of goo, puppeteers, and much more. (Photos from Vittorio)
August 17, 2016
Ever wonder what we get upto in the lab. Well, in recognition of our support for this years Einstein’s Garden at the Green Man Festival, Thomas Gorochowski provides some insight. Read the full interview on Facebook. Photos of the event to follow soon!
May 13, 2016
A team of synthetic biology PhD students from the SynBioCDT have been awarded funding to head to the BDAthlon programming contest taking place in Newcastle this August. The interdisciplinary “Bristol Bug Bashers” team consists of Daniel Dixon a biologist focused on analog computation in living cells, Vittorio Bartoli a chemical engineer implementing negative feedback controllers for use in metabolic engineering, and Jack Steventon a protein designer that uses molecular dynamic simulations to facilitate rational design. Both Daniel and Vittorio are performing short-projects in the lab this summer and we wish them all the best for the competition.
May 06, 2016
The 8th International Workshop on Bio-Design Automation (IWBDA) will be held in Newcastle this year and Daniel Dixon has been awarded a scholarship to attend and present his work! Daniel’s research is focused on analog genetic circuits and uses a mix of modelling and experiments to help guide and potentially automate the creation of new biological devices. This will makes IWBDA the perfect place to present his latest findings and meet the leaders of the field. See you there in August!
April 25, 2016
Cells contain a finite set of resources that must be distributed across many processes with the largest proportion dedicated to protein translation. Synthetic biology often exploits these resources in executing orthogonal genetic circuits, yet the burden this places on the cell is rarely considered. In this work we develop a minimal model that enables us to describe the trade-offs made between endogenous and synthetic genes. We show that simple rules can accurately predict the response of cells, making this model a powerful tool for optimising the efficiency of synthetic gene expression. See the full press release here and the ACS Synthetic Biology paper here.