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PhD Studentship: Tuneable multi-input genetic logic circuits for designer probiotics

Primary supervisor: Thomas Gorochowski (Bristol, UK)
We have a new fully funded 4-year PhD position available within the Biocompute Lab at the University of Bristol, UK. The project will focus on the application of RNA-based technologies for implementing advanced sensing and actuation circuits in living cells, and the development of new methods to allow these to be effectively transferred across species for in situ engineering of microbiomes.

We plan to apply the full arsenal of technologies we have available within our lab to make this project a success covering custom-designed strains, genome design tools, RNA-based genetic circuitry, and high-throughput cellular analytics, including nanopore sequencing and cell sorting.

This project will suit a passionate, ambitious and driven student who wants to push our ability to engineering biology in diverse microbial species. The student will join a highly interdisciplinary, collaborative and friendly research group that strives to make the reliable and safe engineering of biology easier and is not afraid to tackle the big questions and challenges in the field. The student will also benefit from the vibrant engineering biology community within the university and across the wider city (e.g., see Engineering Biology Centre for Doctoral Training, and Science Creates deep tech incubators). This PhD is part of an EPSRC IDLA award, and applicants must be a UK national to be eligible.

To apply, click here, select the ‘Biological Sciences (PhD)’ programme and ensure that Thomas Gorochowski and funding from an EPSRC IDLA is included somewhere in the application. Also ensure that your covering letter includes details about your motivations for a PhD, why you think you’ll make an excellent candidate, and ideas you have for making the project your own (e.g., how might you tackle some part of what is described above).