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EPSRC PhD Studentship

Engineering orthogonal ribosomes as a platform for programmable protein modification

Proteins act as the core molecular machines within living cells and underpin crucial tasks spanning the coordination of metabolism to the self-assembly of structural cytoskeletal components. Many of these diverse functions can be tailored by post-translational modifications of the protein involved (e.g. myristoylation is known to be used for the dynamic control of membrane targeting and protein-protein interactions). However, ensuring that a desired set of modifications is applied to a specific protein of interest is challenging as they often occur post-translationally making their targeting difficult.

To overcome this issue, in this EPSRC-funded project the student will develop orthogonal ribosomes that can be targeted to specific messenger RNAs not recognized by the host cell and allow for the attachment of engineered enzymes that can support the modification of nascent protein chains as translation occurs. To engineer the orthogonal ribosomes the student will employ high-throughput screening approaches using nanopore sequencing to understand the design constraints of the ribosome, and modifying enzyme attachments will be rationally designed using a new protein design tool called Elfin. This project is a rare opportunity to work on emerging technologies for accelerated genetic design with the Biocompute Lab (Thomas Gorochowski) and next-generation protein engineering tools with the Protein Design Lab (Fabio Parmeggiani), as well as join the vibrant biodesign community at the University of Bristol.

The online application form will soon go live, but in the meantime, if you would like to learn more about the project please contact Thomas Gorochowski (thomas.gorochowski@bristol.ac.uk).

Postdocs

Bristol Vice-Chancellor's Fellowships

This scheme offers an exciting opportunity for exceptional early-career researchers to advance their research careers, setup their own group at the University of Bristol. Fellowships are available across the strategic priorities of university. More details...

PhD

For students looking for PhD studentship, we recommend applying to one of the doctoral training centres based at Bristol or associated EU training networks. Any internally funded opportunities will be posted as openings above.

SynBioCDT

The EPSRC and BBSRC Synthetic Biology Centre for Doctoral Training (SynBioCDT) is a 4-year doctoral programme that offers training in the new field of Synthetic Biology, the "Engineering of Biology". This centre is a collaboration between the Universities of Oxford, Bristol and Warwick. More details...

Other

DAAD RISE Worldwide

RISE stands for Research Internships in Science and Engineering. RISE Worldwide offers summer research internships across the world to German undergraduate students with academic training in biology, chemistry, physics, earth sciences, engineering, or a closely related field. RISE Worldwide is funded by the German Federal Ministry of Education and Research. More details...

Biochemical Society Summer Studentships

The Biochemical Society offers grants for stipends of £200 per week for 6–8 weeks, and up to £1,600 in total, to support an undergraduate student to carry out a summer lab placement. The student does not need to be a member of the Society, but when ranking proposals preference will be given to student members. More details...