Sim Castle
PhD Student
Current Appointments:
Previous Appointments:
Education:
MSc Integrated Product Design, TU Delft, 2016
BSc Product Design, University of Sussex, 2013
Interests: synthetic biology, genetic circuits, gene regulatory networks, evolvability, genotype-phenotype map, complexity science, adaptive systems, philosophy of science, philosophy of engineering
Biography
Product designer turned mechanical engineer turned synthetic biologist. I’m interested in developing biological design methods that account for and exploit evolution. In particular, I am applying principles of evolvability to genetic circuit design through experimental and computational study of their genotype-phenotype maps.
All publications
Engineering is evolution: a perspective on design processes to engineer biology
Castle S.D., Stock M., Gorochowski T.E.
Nature Communications 15, 3640, 2024.
Towards an engineering theory of evolution
Castle S.D., Grierson C.S., Gorochowski T.E.
Nature Communications 12, 3326, 2021.
Current Appointments:
Previous Appointments:
Education:
MSc Integrated Product Design, TU Delft, 2016
BSc Product Design, University of Sussex, 2013
Interests: synthetic biology, genetic circuits, gene regulatory networks, evolvability, genotype-phenotype map, complexity science, adaptive systems, philosophy of science, philosophy of engineering
Product designer turned mechanical engineer turned synthetic biologist. I’m interested in developing biological design methods that account for and exploit evolution. In particular, I am applying principles of evolvability to genetic circuit design through experimental and computational study of their genotype-phenotype maps.
Engineering is evolution: a perspective on design processes to engineer biology
Castle S.D., Stock M., Gorochowski T.E.
Nature Communications 15, 3640, 2024.
Towards an engineering theory of evolution
Castle S.D., Grierson C.S., Gorochowski T.E.
Nature Communications 12, 3326, 2021.