Sim Castle

Ph.D. Student

MSc Integrated Product Design, TU Delft, 2016
BSc Product Design, University of Sussex, 2013

Interests: synthetic biology, genetic circuits, gene regulatory networks, evolvability, genotype-phenotype map, complexity science, adaptive systems, philosophy of science, philosophy of engineering

Product designer turned mechanical engineer turned synthetic biologist. I’m interested in developing biological design methods that account for and exploit evolution. In particular, I am applying principles of evolvability to genetic circuit design through experimental and computational study of their genotype-phenotype maps.


All published works


Towards an engineering theory of evolution
Castle S.D., Grierson C.S., Gorochowski T.E.
Nature Communications 12, 3326, 2021.

Talks and Poster Presentations