Single Cycle Master’s Degree in Pharmaceutical Chemistry and Technology, University of Calabria, Italy, 2017
Qualified Pharmacist, 2017
Interests: cell memory, gene editing, synthetic biology, genetic engineering, molecular biology, genetic circuits, biochemistry, pharmaceutical chemistry
I am a Royal Society funded PhD student with a background in Pharmaceutical Chemistry and Technology with expertise in biochemistry, molecular and synthetic biology.
My aim is to investigate the use of a robust information storage medium, DNA, as a writable form of memory, and derive the underlying principles for successful construction of cellular monitoring devices with features leading to rapid switching and robust performance. The rational and predictable engineering of biological systems is a resource for the future scientific research, a weapon to revolutionise ways of thinking and of living with possible applications in a medical environment.
Currently, I am focusing on systematically constructing and measuring the function of cell memory registers and devices in simple hosts employing high-throughput assembly methods and sequencing technologies. In the future, one might think of controlling more complex cells or even whole organisms’ behaviors through cellular logic applied to many different recombinase-based memory registers, potentially resolving great plagues for humanity.
Harnessing the central dogma for stringent multi-level control of gene expression
Greco F.V., Pandi A., Erb E.J., Grierson C.S., Gorochowski T.E.
Nature Communications 12, 1738, 2021.
Design and assembly of multi-level transcriptional and translational regulators for stringent control of gene expression
Greco F.V., Irvine T., Grierson C.S., Gorochowski T.E.
In: Chappell J., Takahashi M.K. (eds) Riboregulator Design and Analysis. Methods in Molecular Biology, 2021. (in press)
Living computers powered by biochemistry
Greco F.V., Tarnowski M.J., Gorochowski T.E.
The Biochemist 41, 14-18, 2019.